---
product_id: 23133825
title: "Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg"
brand: "vetoquinol"
price: "VT32671"
currency: VUV
in_stock: true
reviews_count: 8
category: "Vetoquinol"
url: https://www.desertcart.vu/products/23133825-zylkene-calming-support-supplement-for-large-dogs-33-132lbs-helps
store_origin: VU
region: Vanuatu
---

# Lactose-free & natural ingredients Supports dogs 33-132 lbs 450mg Alpha-Casozephine per capsule Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg

**Brand:** vetoquinol
**Price:** VT32671
**Availability:** ✅ In Stock

## Summary

> 🐾 Calm, Confident Canine Vibes—Because Your Dog Deserves Zen!

## Quick Answers

- **What is this?** Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg by vetoquinol
- **How much does it cost?** VT32671 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.vu](https://www.desertcart.vu/products/23133825-zylkene-calming-support-supplement-for-large-dogs-33-132lbs-helps)

## Best For

- vetoquinol enthusiasts

## Why This Product

- Trusted vetoquinol brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Easy Daily Dose:** Simply open the capsule and mix with food—no pills to chase or force-feed.
- • **Gut-Friendly & Safe:** Lactose-free, ideal for sensitive stomachs, supporting calm behavior without digestive upset.
- • **Stress-Resistant Routine:** Helps dogs thrive through travel, vet visits, loud noises, and separation anxiety.
- • **Natural Milk Protein Formula:** Harnesses Alpha-Casozephine, a bioactive peptide from mother's milk for gentle, effective relaxation.
- • **Vet-Recommended Calming Power:** Trusted by professionals to ease anxiety without drowsiness or side effects.

## Overview

Vetoquinol Zylkene is a veterinarian-recommended, natural calming supplement designed for large dogs (33-132 lbs). Each 450mg capsule delivers Alpha-Casozephine, a milk-derived protein that promotes relaxation and reduces anxiety without sedation. Lactose-free and gentle on sensitive stomachs, it supports daily behavioral health and helps dogs cope with stressors like travel, vet visits, and loud noises. Easy to administer by mixing into food, Zylkene offers a safe, non-prescription solution for enhancing your dog's emotional well-being.

## Description

desertcart.com : Vetoquinol Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg : Pet Supplies

Review: Vetenerian Recommended this product to me Couldn't BE HAPPIER. !!! - I am a Dog Trainer...I have an 8 year old and a 2.5 year old border collies that get along very well with each other. And Yes.. even as a trainer.. My 2.5 year old is fear reactive towards other dogs, and I wasn't able to bring my foster's into the same room with my 2.5 year old or take her places on account of her reactions towards other dogs and sometimes people, this never stopped me from trying to socialize her more and help her cope. I recently adopted another puppy hoping to start out with a younger dog to work on training her to be less reactive. When I took my puppy to the vet for her shots, I discussed with my vet about putting my 2.5 year old on Prozac to help with coping and training. Which I was not to keen on a mind altering drug such a Prozac. My Vet told me about Zylkene and that it is non-prescription, non mind altering and is a natural supplement that contains the same ingredients as mother's milk. Which has a calming effect on dogs. She recommended it for dogs with separation anxiety, fear of thunderstorms and anxiety with car rides etc... So I purchased a bottle from my vet and gave 1 capsule to my 2.5 year old BC. By evening my husband is calling me to see the 2.5 year old and my 12 week old romping, jumping and playing with each other in the yard. I was ecstatic... and almost in tears... she has been on them for 2 weeks every morning with her meals along with training. Her and my puppy or the best of buddies, non-stop playing, sleeping together, and sharing toys. My recent foster was so nervous on car rides and I had to take her to 2 meet and greets. Getting her in and out of the car was a battle. So I decided to try one on her. She did amazing, jumping in and out of the car on her own, no shaking, panting or whining. Dogs that are scared in a car will not take treats and actually eat them. She was mooching as many treats from me as she could, and eating them. I told the Foster group that I work with about Zylkene, and several of them have purchased this product to use during transporting from rescue to foster homes or when we transport fosters to their new homes. I am recommending this to client's, rescues, and friends for their own dogs. This works really well and along with proper training, this does not have to be a life long supplement for your dog.
Review: Miracle for my anxious dog. And I don't say that lightly. - This stuff works MIRACLES for my 2 year old cocker spaniel mix. She's a sweet dog, but very anxious (obsessive, roams around the house whining for unknown reasons, barks when trash bag settles and makes a noise). Seriously felt badly for her. Exercise and keeping her busy wasn't enough to snap her out of those obsessive moods. Vet recommended these capsules and within days, she calmed down significantly (though I admit I was very skeptical, hesitant to attribute the improvement on the pills). I've been giving her one capsule every night before bed for 2 months, and our sweet Olivia is back! She lays on her back for belly rubs, plays with the other house dogs happily, watches our pet bird without losing her mind. Sadly, I lost track and ran out of pills She's been without the pills for a few days for the first time since we started. She is back to obsessing, whining, running around the house aimlessly, trying to crawl up the brick fireplace to get at the birdcage, jumpy when we reach out to pet her, etc. She's never been aggressive (thank goodness), but very sad to see her so on edge! I ordered another bottle as soon as I ran out, but they aren't here yet. I can't wait for them to arrive so I can get this girl back on her meds! And if I can put this on auto-ship, I will DEFINITELY be doing that. I can't let her run out again. The difference is night and day. Skeptic no more. I'm sure this stuff doesn't work for everyone, but if your dog is suffering, this is worth a shot. BTW, the powder inside the capsules tastes HORRIBLE (yeah I tasted it, don't judge)... and there is a lot of it packed into the capsules. So although technically you CAN sprinkle the contents onto/into something if your dog doesn't love taking pills, keep in mind the taste is potent. My dog won't touch it mixed in anything, and if she chews the capsule and it breaks, she quickly spits it out (I was wrapping them in pill masking paste - it worked for a while - now she runs away when she sees the paste). I have to use a pill shooter to get them in her now. TL;DR: Miracle for my anxious dog.

## Features

- Help Your Pet Cope With External Stress - Zylkene helps your pet cope with changes in their daily routine, such as travel, celebrations, vet visits, home alone, boarding, loud noises, and more
- Alpha-Casozephine - A naturally occurring milk protein found in cow's milk that helps promote calming effects in your pet without drowsiness or other side effects found in other calming chews for dogs
- Lactose-Free and Easy on Sensitive Stomachs - Zylkene's dog calming and cat calming supplements are lactose-free and made with natural ingredients that are easy on sensitive stomachs
- Veterinarian Recommended Daily Calming Support - Zylkene promotes calming in dogs and cats and can be given daily for behavior support and to help deal with unexpected external stresses
- Easy to Administer - Open the capsule of Zylkene and add it to your pet's food daily to help them cope with external stresses like separation and improve daily behavior

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Active Ingredients | Alpha-Casozephine |
| Brand | Vetoquinol |
| Customer Reviews | 3.9 out of 5 stars 997 Reviews |
| Flavor | Flavorless |
| Item Form | Capsule |
| Item Weight | 22.68 g |
| Product Benefits | Calming Support |

## Product Details

- **Active Ingredients:** Alpha-Casozephine
- **Brand:** Vetoquinol
- **Flavor:** Flavorless
- **Item Form:** Capsule
- **Item Weight:** 0.05 Pounds

## Images

![Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg - Image 1](https://m.media-amazon.com/images/I/71lbfxi7KqL.jpg)

## Available Options

This product comes in different **Size** options.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Vetenerian Recommended this product to me Couldn't BE HAPPIER. !!!
*by P***S on December 20, 2016*

I am a Dog Trainer...I have an 8 year old and a 2.5 year old border collies that get along very well with each other. And Yes.. even as a trainer.. My 2.5 year old is fear reactive towards other dogs, and I wasn't able to bring my foster's into the same room with my 2.5 year old or take her places on account of her reactions towards other dogs and sometimes people, this never stopped me from trying to socialize her more and help her cope. I recently adopted another puppy hoping to start out with a younger dog to work on training her to be less reactive. When I took my puppy to the vet for her shots, I discussed with my vet about putting my 2.5 year old on Prozac to help with coping and training. Which I was not to keen on a mind altering drug such a Prozac. My Vet told me about Zylkene and that it is non-prescription, non mind altering and is a natural supplement that contains the same ingredients as mother's milk. Which has a calming effect on dogs. She recommended it for dogs with separation anxiety, fear of thunderstorms and anxiety with car rides etc... So I purchased a bottle from my vet and gave 1 capsule to my 2.5 year old BC. By evening my husband is calling me to see the 2.5 year old and my 12 week old romping, jumping and playing with each other in the yard. I was ecstatic... and almost in tears... she has been on them for 2 weeks every morning with her meals along with training. Her and my puppy or the best of buddies, non-stop playing, sleeping together, and sharing toys. My recent foster was so nervous on car rides and I had to take her to 2 meet and greets. Getting her in and out of the car was a battle. So I decided to try one on her. She did amazing, jumping in and out of the car on her own, no shaking, panting or whining. Dogs that are scared in a car will not take treats and actually eat them. She was mooching as many treats from me as she could, and eating them. I told the Foster group that I work with about Zylkene, and several of them have purchased this product to use during transporting from rescue to foster homes or when we transport fosters to their new homes. I am recommending this to client's, rescues, and friends for their own dogs. This works really well and along with proper training, this does not have to be a life long supplement for your dog.

### ⭐⭐⭐⭐⭐ Miracle for my anxious dog. And I don't say that lightly.
*by M***K on October 28, 2016*

This stuff works MIRACLES for my 2 year old cocker spaniel mix. She's a sweet dog, but very anxious (obsessive, roams around the house whining for unknown reasons, barks when trash bag settles and makes a noise). Seriously felt badly for her. Exercise and keeping her busy wasn't enough to snap her out of those obsessive moods. Vet recommended these capsules and within days, she calmed down significantly (though I admit I was very skeptical, hesitant to attribute the improvement on the pills). I've been giving her one capsule every night before bed for 2 months, and our sweet Olivia is back! She lays on her back for belly rubs, plays with the other house dogs happily, watches our pet bird without losing her mind. Sadly, I lost track and ran out of pills She's been without the pills for a few days for the first time since we started. She is back to obsessing, whining, running around the house aimlessly, trying to crawl up the brick fireplace to get at the birdcage, jumpy when we reach out to pet her, etc. She's never been aggressive (thank goodness), but very sad to see her so on edge! I ordered another bottle as soon as I ran out, but they aren't here yet. I can't wait for them to arrive so I can get this girl back on her meds! And if I can put this on auto-ship, I will DEFINITELY be doing that. I can't let her run out again. The difference is night and day. Skeptic no more. I'm sure this stuff doesn't work for everyone, but if your dog is suffering, this is worth a shot. BTW, the powder inside the capsules tastes HORRIBLE (yeah I tasted it, don't judge)... and there is a lot of it packed into the capsules. So although technically you CAN sprinkle the contents onto/into something if your dog doesn't love taking pills, keep in mind the taste is potent. My dog won't touch it mixed in anything, and if she chews the capsule and it breaks, she quickly spits it out (I was wrapping them in pill masking paste - it worked for a while - now she runs away when she sees the paste). I have to use a pill shooter to get them in her now. TL;DR: Miracle for my anxious dog.

### ⭐⭐⭐⭐ CALMS MY DOGS NERVES
*by R***T on April 18, 2019*

Zylkene capsules seem to be working really well, my dog is nervous anytime we go out of her comfort zone of our house or car. I give one of these capsules with her breakfast every morning, and it does seem to help all day. It is made to feed as a supplement, and there is no vet prescription needed. It is a little on the expensive side for a Calming aid for you pet, but if it helps, it is well worth every penny. My vet told me about it, so thought is was worth the try. It does seem to calm my dogs nerves!

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*Product available on Desertcart Vanuatu*
*Store origin: VU*
*Last updated: 2026-03-15*