--- product_id: 257288700 title: "THORNE Methyl-Guard - Supports Methylation for Healthy Heart, Blood Vessels, Brain & Bones* - Vitamins B6 & B12, Folate (5-MTHF) & Betaine - Gluten, Dairy & Soy-Free - 180 Capsules" brand: "thorne" price: "VT27673" currency: VUV in_stock: true reviews_count: 5 category: "Thorne" url: https://www.desertcart.vu/products/257288700-thorne-methyl-guard-supports-methylation-for-healthy-heart-blood-vessels store_origin: VU region: Vanuatu --- # 180 potent capsules Boosts brain & nerve health Supports heart & vessels THORNE Methyl-Guard - Supports Methylation for Healthy Heart, Blood Vessels, Brain & Bones* - Vitamins B6 & B12, Folate (5-MTHF) & Betaine - Gluten, Dairy & Soy-Free - 180 Capsules **Brand:** thorne **Price:** VT27673 **Availability:** ✅ In Stock ## Summary > ⚡ Elevate your wellness game with Methyl-Guard — where science meets elite vitality! ## Quick Answers - **What is this?** THORNE Methyl-Guard - Supports Methylation for Healthy Heart, Blood Vessels, Brain & Bones* - Vitamins B6 & B12, Folate (5-MTHF) & Betaine - Gluten, Dairy & Soy-Free - 180 Capsules by thorne - **How much does it cost?** VT27673 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.vu](https://www.desertcart.vu/products/257288700-thorne-methyl-guard-supports-methylation-for-healthy-heart-blood-vessels) ## Best For - thorne enthusiasts ## Why This Product - Trusted thorne brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Clean & Pure:** Gluten, dairy, soy, and shellfish-free to fit your clean-living lifestyle without compromise. - • **Long-Lasting Supply:** One capsule daily delivers a 6-month supply, making premium wellness effortless and economical. - • **Methylation Mastery:** Optimized active B vitamins (5-MTHF & methylcobalamin) for superior absorption and cellular support. - • **Trusted by Champions:** Endorsed by 100+ pro sports teams and top healthcare practitioners for unmatched quality and efficacy. - • **Holistic Health Boost:** Clinically designed to support heart, blood vessels, brain, nerves, and bones — all in one formula. ## Overview THORNE Methyl-Guard is a premium methylation support supplement featuring active, methylated forms of folate (5-MTHF) and vitamin B12 (methylcobalamin). Designed to promote healthy heart, blood vessel, brain, nerve, and bone function, it offers a clean, allergen-free formula trusted by professional athletes and healthcare experts alike. With 180 capsules per bottle, it provides a convenient 6-month supply of advanced B-vitamin support. ## Description THORNE Methyl-Guard - Supports Methylation for Healthy Heart, Blood Vessels, Brain & Bones* - Vitamins B6 & B12, Folate (5-MTHF) & Betaine - Gluten, Dairy & Soy-Free - 180 Capsules : desertcart.ae: Automotive Review: Excellent product for MTHFR genetic disorder Review: good product ## Features - Methylation: Support for healthy methylation* - Multiple Functions: Support for heart, blood vessel, brain, nerve, and bone health* - Homocysteine: Promotes homocysteine metabolism* - Active Bs: Contains the active, methylated forms of folate and vitamin B12 (5-MTHF and methylcobalamin) - Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey) ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B0012FJVA2 | | Age Range Description | Adult | | Allergen Information | Shellfish Free | | Best Sellers Rank | #641 in Health ( See Top 100 in Health ) #43 in Multiple Vitamin-Mineral Combination Supplements | | Brand | THORNE | | Brand Name | THORNE | | Color | red | | Container Type | Bottle | | Country of Publication | USA | | Customer Reviews | 4.7 out of 5 stars 1,056 Reviews | | Diet Type | Gluten Free | | Diet type | Gluten Free | | Dosage Form | Capsule | | Flavor | Unflavored | | Flavour | Unflavored | | Global Trade Identification Number | 00693749787037 | | Item Dimensions | 7.3 x 7.3 x 13.3 centimeters | | Item Form | Capsule | | Item Weight | 180 Milligrams | | Item form | Capsule | | Manufacturer | Thorne Research | | Manufacturer Part Number | SF787-R | | Material Type Free | en_AE | | Model Name | Methyl-Guard | | Number of Items | 1 | | Primary Supplement Type | Vitamin B and Folate | | Primary supplement type | Vitamin B and Folate | | Product Benefits | Bone Health Support | | Product benefits | Bone Health Support | | Specific Uses For Product | Heart | | UPC | 693749787037 885335121343 884733360033 885100656025 881619227596 | | Unit Count | 180.0 Count | ## Product Details - **Brand:** THORNE - **Diet type:** Gluten Free - **Flavour:** Unflavored - **Item form:** Capsule - **Primary supplement type:** Vitamin B and Folate ## Images ![THORNE Methyl-Guard - Supports Methylation for Healthy Heart, Blood Vessels, Brain & Bones* - Vitamins B6 & B12, Folate (5-MTHF) & Betaine - Gluten, Dairy & Soy-Free - 180 Capsules - Image 1](https://m.media-amazon.com/images/I/61kCTgAaeVL.jpg) ## Available Options This product comes in different **Style** options. ## Questions & Answers **Q: Is there a scientific study that I can read that will back up these claims?** A: Absolutely, there are studies! There are enough that I need to ask you to be more precise in what you want to know. Which ingredient are you interested in, for what population, and concerning what symptoms? Your local library may be able to help you access research databases that will allow you to search to your heart's content. State libraries may be used by any taxpayer, and some medical schools will allow community members a day pass. Here is a little taste, notice how long this research has been going on: 1) Weisberg, I., Tran, P., Christensen, B., Sibani, S., & Rozen, R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular genetics and metabolism, 64(3), 169-172.2) Grandone, E., Margaglione, M., Colaizzo, D., Cappucci, G., Paladini, D., Martinelli, P., ... & Di Minno, G. (1997). Factor V Leiden, C> T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thrombosis and haemostasis, 77(6), 1052-1054.3) (The title for this one is unfortunate, it is a randomized, controlled clinical study which is the gold standard, and it found the reduced B vitamins to work to alleviate symptoms of major depression as well as homocystine levels. 4) Sontag, J.-M., Wasek, B., Taleski, G., Smith, J., Arning, E., Sontag, E., & Bottiglieri, T. (2014). Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in Aging Neuroscience, 6, 214. http://doi.org/10.3389/fnagi.2014.00214There is your taste! There is also research showing lack of/poor sperm count in males with homozygous A1298C variant of MTHFR, higher risks of pre-eclampsia in pregnant women, etc., etc., At this point, I'm surprised that routine screening has not yet become a standard of care. I hope that the variation of research articles here has helped you to understand why a more precise question is needed for a direct answer. No single study will do it (and never does). How about 2 decades of research? :) **Q: Ingredients?** A: There seems to be some confusion about the difference between Methyl-Guard and Methyl-Guard PLUS, which costs twice as much as the regular Methyl-Guard listed on this page.Jana B.'s answers above seem to list the ingredients of the plus version, although the amounts appear to match that of the regular version. (?)This version does NOT have Riboflavin (B2) (Riboflavin 5'-Phosphate Sodium). In addition to B2, the plus version also claims to have more of all of the ingredients listed below.I have never purchased MG-Plus but I have a bottle of the regular Methyl-Guard in front of me.Here are the ingredients as listed:3 capsules contain:Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,020% DVFolate (as L-5 Methyltetrahydrofolate from L-5 Methyltetrahydrofolic Acid, Glucosamine Salt) 1.2 mg 300% DVVitamin B12 (as Methylcobalamin) 1.2 mg 20,000% DVBetaine Anhydrous (Trimethylglycine) 1.8 g *DV not establishedOther Ingredients:Hypromellose (derived from cellulose) capsuleCalciumCitrateLaurate (sic)Silicon DioxideSuggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner. (Personally, I only take 3 a day, not 6) **Q: This states 180 capsules???** A: Thorne Research - Methyl-Guard comes in a 180 capsule sized bottle. **Q: What is the difference between the old label and the new label?** A: Also some of the amounts are different. Old methyl guard: Three Capsules Contain: Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg. Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE Vitamin B12 (as Methylcobalamin) 1.2 mg. Betaine Anhydrous (Trimethylglycine) 1.8 g. New Methyl guard Plus: Three Capsules Contain: Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE Vitamin B12 (as Methylcobalamin) 3 mg Betaine Anhydrous (Trimethylglycine) 1.8 g This is from the thorne research website. I love the old one (helps with depression) but the plus gives me a migraine. ## Customer Reviews ### ⭐⭐⭐⭐⭐ Excellent product for MTHFR genetic disorder *by C***Y on 11 September 2025* ### ⭐⭐⭐⭐⭐ good product *by J***H on 6 May 2026* ### ⭐⭐⭐⭐⭐ Great for vitamin B deficiencies *by T***S on 7 October 2024* ## Frequently Bought Together - THORNE Methyl-Guard - Methylation Support Supplement* with Folate and Vitamin B12-180 Capsules - THORNE Vitamin D-5000 - Vitamin D3 Supplement - Support Healthy Bones, Teeth, Muscles, Cardiovascular, and Immune Function* - NSF Certified for Sport - Dairy-Free, Soy-Free - 60 Capsules - THORNE Berberine - Dual Action Formula with Phytosome Plus Botanical Extract - Support Heart Health, Immune System, Healthy GI, Cholesterol* - Gluten-Free, Dairy-Free - 60 Capsules - 30 Servings --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.vu/products/257288700-thorne-methyl-guard-supports-methylation-for-healthy-heart-blood-vessels](https://www.desertcart.vu/products/257288700-thorne-methyl-guard-supports-methylation-for-healthy-heart-blood-vessels) --- *Product available on Desertcart Vanuatu* *Store origin: VU* *Last updated: 2026-05-16*