---
product_id: 326301694
title: "Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 16.9 fl. oz. (500mL)"
brand: "douxo"
price: "VT21178"
currency: VUV
in_stock: true
reviews_count: 11
category: "Douxo"
url: https://www.desertcart.vu/products/326301694-douxo-s3-pyo-shampoo-contains-3-chlorhexidine-and-0-5
store_origin: VU
region: Vanuatu
---

# 0.5% Ophytrium natural skin barrier support 500mL vet-recommended volume 3% Chlorhexidine antiseptic power Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 16.9 fl. oz. (500mL)

**Brand:** douxo
**Price:** VT21178
**Availability:** ✅ In Stock

## Summary

> 🐕‍🦺 Elevate your pet’s skin game — vet-approved, science-backed, and irresistibly soothing!

## Quick Answers

- **What is this?** Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 16.9 fl. oz. (500mL) by douxo
- **How much does it cost?** VT21178 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.vu](https://www.desertcart.vu/products/326301694-douxo-s3-pyo-shampoo-contains-3-chlorhexidine-and-0-5)

## Best For

- douxo enthusiasts

## Why This Product

- Trusted douxo brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Clean & Gentle:** Free from soaps, sulfates, parabens, dyes, and nanoparticles for sensitive skin
- • **Perfect Pairing:** Maximize results when used with DOUXO PYO Mousse for a complete skin care regimen
- • **Vet-Trusted Formula:** Top non-prescription choice by U.S. veterinarians for skin infections and inflammation
- • **Rapid Relief & Hydration:** Clinically proven to reduce yeast counts and soothe irritated skin within 7 days
- • **Dual-Action Antiseptic & Moisturizer:** Combines antibacterial chlorhexidine with hydrating ophytrium for balanced skin health

## Overview

S3 Pyo Shampoo is a 500mL antiseptic and hydrating formula containing 3% chlorhexidine and 0.5% ophytrium, designed to treat bacterial and yeast skin infections in dogs and cats. Recommended by U.S. veterinarians, it cleanses, soothes, and supports the skin barrier without harsh chemicals, delivering visible relief and healthier skin in just one week.

## Description

Formulated with antibacterial and antifungal ingredients to help soothe, clean and strengthen the skin barrier. Moisturizes and detangles the fur to leave the coat soft and shiny. DOUXO is the 1 non-prescription topical brand used and recommended by U.S. veterinarians for treatment of dogs and cats with infections/inflammatory dermatological diseases.

Review: Great Product, Immediate Relief - Easy and reliable to pump shampoo out, lathered very well on thick double coat, less redness and irritation right out of the shower, pleasant smell - nothing to complain about.
Review: Amazing Stuff - fixed my dog's skin issues! - My dog had maybe a yeast infection, skin allergies... idk. He had scabs and dandruff all over his back and belly, and lots of discoloration on his belly which came out of nowhere, He was constantly itching and I felt so bad for him ): I decided to look into it and found people with similar issues. So, with recommendations, I found this shampoo, and also switched his dog food to a better one. With the switch of his dog food, I can't say that one or the other fixed his skin, or both was the solution, but either way, his skin and coat has made a DRASTIC change in just one month. I have been washing him every 3-4 days with this shampoo for a month now, scrubbing him very well and leaving it to sit on him for 5-10 mins. He hates baths but it's what we have to do! This stuff smells great, it suds up and has a nice lather, rinses well, and leaves his coat feeling soft and clean! I can't complain at all. Yes it is pricey as heck, but if it works how can I complain. when I was researching on the internet for my dog's specific issues, I saw people with similar issues say their dog had a yeast infection, and when they took their dog to the vet, this is what their vet recommended! This is what made me take the jump on the purchase and I was not disappointed.

## Features

- #1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs and cats with infections/inflammatory dermatological disease
- Proven to clean, hydrate and help support the skin's ecosystem and reduce yeast counts in 7 days
- Contains ophytrium, a purified natural ingredient that helps support the skin’s physical barrier for supple hydrated skin and helps soothe irritated skin
- Free from soaps, sulfates, parabens, dyes and nanoparticles
- For best results use with the DOUXO PYO Mousse

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0949RKDYC |
| ASIN  | B0949RKDYC |
| Age Range Description | All Life Stages |
| Allergen Information | Hypoallergenic |
| Best Sellers Rank | #407 in Pet Supplies ( See Top 100 in Pet Supplies ) #3 in Dog Shampoos |
| Brand Name | Douxo |
| Color | Translucent |
| Customer Reviews | 4.7 4.7 out of 5 stars (6,961) |
| Date First Available | May 6, 2021 |
| Date First Available  | May 6, 2021 |
| Directions | Use as recommended by your veterinarian. Wet the fur with cool water from the neck down. Using 1 pump for every 4 lbs, gently massage shampoo onto skin abnormalities to reach the skin. Repeat until entire body is lightly coated with shampoo and leave on for 10 minutes. Rinse thoroughly with cool water. Shampoo amount can be doubled for dogs or cats with long and/or thick fur. |
| Included Components | Shampoo |
| Item Package Dimensions L x W x H | 7.52 x 3.41 x 2.01 inches |
| Item Weight | 16.9 Ounces |
| Item model number | D98420E |
| Item model number  | D98420E |
| Liquid Volume | 500 Milliliters |
| Manufacturer | Douxo S3 |
| Manufacturer  | Douxo S3 |
| Model Name | PYO |
| Number of Items | 1 |
| Package Dimensions  | 7.52 x 3.41 x 2.01 inches; 1.06 Pounds |
| Size | 16.9 oz |
| Special Ingredients | chlorhexidine, ophytrium |
| Specific Uses for Product | anti-fungal-anti-bacterial |
| Target Audience Keyword | Cats, Dogs, dogs |
| Target Species | dog, cat |
| UPC | 850002593433 |

## Product Details

- **Brand:** Douxo
- **Item Form:** Shampoo
- **Product Benefits:** Anti-Fungal
- **Recommended Uses For Product:** Irritated Skin,Moisturizing
- **Scent:** coconut and vanilla

## Images

![Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 16.9 fl. oz. (500mL) - Image 1](https://m.media-amazon.com/images/I/61yhoJoV-IL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: What happened to the original formula that had these active ingredients: chlorhexadine 3%, climbazole .5%, phytosphingosine salicyloyl .05%??????**
A: I talked to my Dog's Allergy Vet's office recently about this. They told me they reformulated this and took out some ingredients due to some Dog's having a reaction to it. Also, I don't like it and its nothing like the original formula. It doesn't suds up and I had to use more than double the amount the directions said on my 8 lb dog.

**Q: I'm using the other brand of Douxo for my dog's skin allergies. How does this compare to the other Douxo?**
A: This product is specifically designed to relieve bacterial or fungal skin infections. Specifically, it helps to soothe irritated skin. If your dog has skin allergies, this particular shampoo could be a good choice since it is the #1 non-prescription topical brand used and recommended by U.S. veterinarians.

**Q: Why doesn't it say antifungal any more? it still says it in the description but no longer on the bottle? why?**
A: Mine says antifungal anticeptic

**Q: Who can i message that sells this product?**
A: We do :)

## Customer Reviews

### ⭐⭐⭐⭐⭐ Great Product, Immediate Relief
*by M***G on January 28, 2026*

Easy and reliable to pump shampoo out, lathered very well on thick double coat, less redness and irritation right out of the shower, pleasant smell - nothing to complain about.

### ⭐⭐⭐⭐⭐ Amazing Stuff - fixed my dog's skin issues!
*by T***S on November 3, 2025*

My dog had maybe a yeast infection, skin allergies... idk. He had scabs and dandruff all over his back and belly, and lots of discoloration on his belly which came out of nowhere, He was constantly itching and I felt so bad for him ): I decided to look into it and found people with similar issues. So, with recommendations, I found this shampoo, and also switched his dog food to a better one. With the switch of his dog food, I can't say that one or the other fixed his skin, or both was the solution, but either way, his skin and coat has made a DRASTIC change in just one month. I have been washing him every 3-4 days with this shampoo for a month now, scrubbing him very well and leaving it to sit on him for 5-10 mins. He hates baths but it's what we have to do! This stuff smells great, it suds up and has a nice lather, rinses well, and leaves his coat feeling soft and clean! I can't complain at all. Yes it is pricey as heck, but if it works how can I complain. when I was researching on the internet for my dog's specific issues, I saw people with similar issues say their dog had a yeast infection, and when they took their dog to the vet, this is what their vet recommended! This is what made me take the jump on the purchase and I was not disappointed.

### ⭐⭐⭐⭐⭐ 5 Stars - HIGHLY Recommend! Works Amazing for Allergies!
*by H***R on September 15, 2025*

Hands down the best dog shampoo I've ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he's allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I'm averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I'll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent! The smell is really great as well, it's a lighter scent, I don't smell any chemicals or any of the normal medicated smell at all & it's light enough you can smell it on your pup if you're up close, but otherwise it's not noticeable. The formula is decently thick, it's not runny at all, but it suds up so great as well - another huge thing most medicated shampoos don't do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it's so easy to suds up, that you don't need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that's about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don't have to worry about it leaking, we transport it every weekend to our MIL's house, and I just throw it in the bag, never leaked before, you don't have to worry about it. I can't recommend this shampoo enough or stress how well its been working for our 4 dogs!

## Frequently Bought Together

- Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 16.9 fl. oz. (500mL)
- Douxo S3 Pyo Mousse, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, for Bacterial or Yeast Skin Infections, for Dogs, 5.1 fl. oz. (150mL)
- Douxo S3 Pyo Pads, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 30 Pads

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*Product available on Desertcart Vanuatu*
*Store origin: VU*
*Last updated: 2026-02-23*