---
product_id: 51457228
title: "Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules"
brand: "zylkene"
price: "VT21736"
currency: VUV
in_stock: true
reviews_count: 13
category: "Zylkene"
url: https://www.desertcart.vu/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg
store_origin: VU
region: Vanuatu
---

# natural milk protein (alpha casozepine) for large dogs 30-60kg 450mg potent calming dose Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules

**Brand:** zylkene
**Price:** VT21736
**Availability:** ✅ In Stock

## Summary

> 🐾 Calm in Every Capsule — Because Your Big Dog Deserves Peace of Mind

## Quick Answers

- **What is this?** Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules by zylkene
- **How much does it cost?** VT21736 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.vu](https://www.desertcart.vu/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg)

## Best For

- zylkene enthusiasts

## Why This Product

- Trusted zylkene brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Easy Food Integration:** Capsules open to sprinkle on food—no stress, no fuss
- • **Non-Drowsy Relaxation:** Keeps your dog calm and alert, perfect for active lifestyles
- • **Versatile Calm Anywhere:** Supports pets through fireworks, social events, travel, and home chaos
- • **Vet-Trusted Calming Power:** UK's No.1 vet-recommended supplement for anxiety relief
- • **Natural & Clinically Proven:** Harnesses alpha casozepine, a milk-derived protein with proven calming effects

## Overview

Zylkene Calming Supplements deliver 450mg of alpha casozepine, a natural milk protein clinically proven to ease anxiety in large dogs (30-60kg). Trusted by vets and behaviourists across the UK, these easy-to-administer capsules help pets stay relaxed during short-term stressors like loud noises and social gatherings without causing drowsiness. Simply sprinkle on food for fast-acting, non-invasive support that fits seamlessly into your dog's routine.

## Description

From the brand Providing the calm in the chaos for every cat and dog, wherever they go. Zylkene contains a natural milk protein with clinically proven calming effects to help support your cat and dog during challenging situations Help pets cope with challenging situations inside and outside the home: Helps ease anxiety Non-drowsy Promotes relaxation Providing the calm in the chaos for every cat and dog, wherever they go. Zylkene contains a natural milk protein with clinically proven calming effects to help support your cat and dog during challenging situations Help pets cope with challenging situations inside and outside the home Helps ease anxiety Non-drowsy Promotes relaxation Shop Zylkene Caps Visit the store Shop Zylkene Caps Visit the store Shop Zylkene Chews Visit the store Shop Zylkene Chews Shop Zylkene Plus Visit the store Shop Zylkene Plus How does Zylkene work? Zylkene calming supplement contains a natural ingredient derived from a protein in milk called casein that has clinically proven calming effects and helps comfort cats & dogs. Is Zylkene suitable for general everyday use? Zylkene is suitable for both long and short-term use. For long-term use, we recommend giving Zylkene to your pet every day for a month, then reassessing and continuing if needed. How long does Zylkene take to work? We recommend giving Zylkene 1-2 days before the predicted challenging event or when a change in their environment is expected to happen. How does Zylkene work? Zylkene calming supplement contains a natural ingredient derived from a protein in milk called casein that has clinically proven calming effects and helps comfort cats & dogs. Is Zylkene suitable for general everyday use? Zylkene is suitable for both long and short-term use. For long-term use, we recommend giving Zylkene to your pet every day for a month, then reassessing and continuing if needed. How long does Zylkene take to work? We recommend giving Zylkene 1-2 days before the predicted challenging event or when a change in their environment is expected to happen.

Review: OMG I cant praise this enough - If I could give this ten stars I would ! We have an old dog suffering from dementia. He is physically in excellent health but was suffering from severe stress and a condition named Sundown which was very horrible for him. He would become seriously agitated at night and pace in circles wimping. During the day he hardly responded and his eyes looked vacant and dull. We were at the point of having him pts. I remembered using the equine version on a horse and it worked to settle him in competition. So I gave it a go not really very hopefull. Within two days he was more settled. He continued to improve and has been on it now for a month and the Sundown no longer bothers him. His eyes are bright and he is now enjoying life. No longer dragging on walks and his appetite is healthy again. He is still an old dog but a normal old dog. No longer stressed and confused. No pacing and staring. I cant beleive the difference we have our dog back. He is fed the dose for a large dog although he is a labrador and med.
Review: Great but open the capsule 💊 not to be given whole - Doing ok so far watch out though !!!!!! I didn’t read the packet and you DO NOT GIVE AS A TABLET !! You break open the capsule 💊 and empty on food !! Didn’t do that 1st time so hope he will be ok 👌🏻 so stupid of me !! As they were capsules 💊 so I didn’t think ?

## Features

- Zylkene (450mg) is a calming supplement for large dogs (30 to 60kg) to help them cope with short-term challenging situations such as fireworks and social gatherings
- UK's No. 1 Veterinary Calming Supplement*, widely used and trusted by vets, behaviourists and pet owners *Kynetec market data, MAT May 2023
- Suitable for challenging situations inside and outside the home so cats & dogs can feel calm wherever they are
- Contains alpha casozepine – a natural milk protein with clinically proven calming properties
- Can easily be sprinkled on to your pet's food - absorbed internally providing action for pets in and out of the home

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00K06M9QC |
| Age Range Description | Adult |
| Allergen Information | Allergen-Free |
| Benefits | Brain Health Support |
| Best Sellers Rank | 605 in Pet Supplies ( See Top 100 in Pet Supplies ) 33 in Relaxants & Anxiety Relief for Dogs |
| Brand Name | Zylkene |
| Colour | White & Blue |
| Country Of Origin | France |
| Customer Reviews | 4.0 4.0 out of 5 stars (401) |
| Dosage Form | Capsule |
| Flavour | Unflavoured |
| Included Components | nil |
| Item Dimensions | 6 x 6 x 17 centimetres |
| Item Form | Capsule |
| Item Nype Name | Relaxants & Anxiety Relief for Large Dogs |
| Item Weight | 450 Milligrams |
| Manufacturer | Vetoquinol |
| Manufacturer Contact Information | Vetoquinol UK Ltd, Steadings Barn, Pury Hill Business Park, Nr Alderton, Towcester, Northamptonshire NN12 7LS |
| Model Name | Zylkene |
| Number of Items | 1 |
| Primary Supplement Type | Casein |
| Product Warranty | 2 year manufacturer |
| Specific Uses For Product | Behaviour |
| Unit Count | 20.0 count |

## Product Details

- **Brand:** Zylkene
- **Flavour:** Unflavoured
- **Item form:** Capsule
- **Primary supplement type:** Casein
- **Product benefits:** Brain Health Support

## Images

![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 1](https://m.media-amazon.com/images/I/71hWFQgX5nL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: What is the best time to give**
A: Zylkene is suitable for both short- and long-term use. 
For short term use we recommend you begin administration 1 or 2 days before the predicted stressful event. For long term use, give Zylkene to your pet every day for a month then reassess their needs and continue if needed.
We recommend talking to your vet if it is a long-term problem to make sure there are no underlying issues.

We hope this information was useful! The Zylkene Team.

**Q: Why is The packaging is all in foreign?**
A: If it is a foreign supplier, I imagine the info will not be in English, I always search for UK seller.

**Q: I have a 4 month old kitten is it safe to give her these please?**
A: My kitten is 2 mouths old and my vet prescribed me this medication for him . Unfortunately I didn’t see any difference yet .

**Q: How long does it take to work?**
A: used to calm our dog before going to the groomers , started 3 days before our appointment giving 2 tablets daily . Originally prescribed by our vet and those were dosage recommended

## Customer Reviews

### ⭐⭐⭐⭐⭐ OMG I cant praise this enough
*by A***T on 25 March 2026*

If I could give this ten stars I would ! We have an old dog suffering from dementia. He is physically in excellent health but was suffering from severe stress and a condition named Sundown which was very horrible for him. He would become seriously agitated at night and pace in circles wimping. During the day he hardly responded and his eyes looked vacant and dull. We were at the point of having him pts. I remembered using the equine version on a horse and it worked to settle him in competition. So I gave it a go not really very hopefull. Within two days he was more settled. He continued to improve and has been on it now for a month and the Sundown no longer bothers him. His eyes are bright and he is now enjoying life. No longer dragging on walks and his appetite is healthy again. He is still an old dog but a normal old dog. No longer stressed and confused. No pacing and staring. I cant beleive the difference we have our dog back. He is fed the dose for a large dog although he is a labrador and med.

### ⭐⭐⭐⭐⭐ Great but open the capsule 💊 not to be given whole
*by M***R on 28 March 2026*

Doing ok so far watch out though !!!!!! I didn’t read the packet and you DO NOT GIVE AS A TABLET !! You break open the capsule 💊 and empty on food !! Didn’t do that 1st time so hope he will be ok 👌🏻 so stupid of me !! As they were capsules 💊 so I didn’t think ?

### ⭐⭐⭐⭐ Nothing worked to calm my dog, He had massive ...
*by P***A on 24 September 2017*

Nothing worked to calm my dog, He had massive anxiety at night, tried calming spray, rescue remedy, vet prescribed antidepressants and sedatives which just made him fall over. Tried Zylkene, worked within 3 nights, very excited to be able to sleep myself so ordered loads more, sadly I think my pooch has got used to it, we now have sleep about 4 out of 7 nights which is a bonus. He is a large dog on 450mg X2 . Worth a try, expensive but anything is worth a nights sleep.

## Frequently Bought Together

- Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pet Anxiety | Helps Pets cope with short-term challenging situations | Easily administered | 20 capsules
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*Product available on Desertcart Vanuatu*
*Store origin: VU*
*Last updated: 2026-05-17*