RayBiotech Rabbit Anti-Human pro-BNP (NPPB) [+Biotin] Antibody Gene ID 4879, 50 µg 130-10043B-50

Description

Brain natriuretic peptide (BNP) is a polypeptide of 134-amino acids comprised of a 26-amino acid signal peptide (Met1-Ser26), a 76-amino acid N-terminal fragment (NT-proBNP) (His27-Arg102), and a 32-amino acid mature polypeptide of brain natriuretic peptide 32 (BNP-32)(Ser103-His134). BNP-32 is secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). BNP-32 is cosecreted along with NT-proBNP which is biologically inactive. Both BNP-32 and NT-proBNP markers are used for screening, diagnosis of acute congestive heart failure (CHF). The plasma concentrations of both BNP and NTproBNP are also typically increased in patients with asymptomatic/symptomatic left ventricular dysfunction.. Immunogen: Immunogen was human expressed proBNP long peptide(76 Amino acid of N-terminal fragment). This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation, and followed by Protein A/G affinity chromatography. Isotype: IgG.