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🦴 Boost your pet’s playtime and longevity with nature’s immune elite!
Critical Immune Defense is a vet-developed, mushroom-based powder supplement featuring Turkey Tail, Reishi, Shiitake, Maitake, and patented white turmeric extract. Designed to support normal cell growth, reduce inflammation, and enhance immune resilience in dogs and cats of all ages and breeds. Made in the USA with premium natural ingredients, it promotes vitality and long-term health, helping pets stay active and protected against common health challenges.






| ASIN | B07FWPPGWT |
| ASIN | B07FWPPGWT |
| Best Sellers Rank | #3,217 in Pet Supplies ( See Top 100 in Pet Supplies ) #11 in Dog Herbal Supplements |
| Brand Name | VetSmart Formulas |
| Customer Reviews | 4.3 4.3 out of 5 stars (1,792) |
| Date First Available | November 25, 2019 |
| Dog Breed Size | Large |
| Flavor | Hypo-allergenic Chicken Flavor |
| Included Components | Critical Immune Defense |
| Item Form | Powder |
| Item Weight | 6.34 Ounces |
| Item model number | CID |
| Manufacturer | Pet Wellness Direct |
| Manufacturer | Pet Wellness Direct |
| Manufacturer Part Number | CID |
| Model Number | CID |
| Package Dimensions | 4.88 x 2.72 x 2.68 inches; 6.34 ounces |
| Specific Uses For Product | Immune Defense |
| Target Species | Cat |
| UPC | 691327266288 |
| Unit Count | 6.34 Ounce |
| Warranty Description | Three Years From Manufacturing Date As Indicated On Each Jar |
C**R
I AM BACK TO BUY MORE!
Update: We have only one bottle of powder left, so I'm reordering. I still have my grand-dog, Gus, on this supplement, and he is still running and chasing the ball during play time. My son is a firm believer in this product, and so am I. I have my younger female dogs on it as well. It is costly, but when I consider eventual vet bills that might be prevented if dogs have this stuff all their lives, I prefer to keep them healthy now so we can avoid some of the absurdly expensive health issues later in life. I can't seem to leave a vet's office without a three-hundred-dollar bill, and that is for basically nothing. Anything serious can be one or two thousand or much higher. It strikes me as being smarter to try to prevent serious issues for as long as we can, and in the meantime, our three dogs are happy, healthy, and enjoying a good playtime with the ball every day. At mealtime, they don't hesitate to eat, and if we didn't get all the powder mixed in well with their food, they lick the bowls clean, getting every last bit of the supplement. After eating, they circle around to see if another dog left any traces of anything in the bowl, and if one misses some of this supplement powder, they lick it up. So it doesn't taste icky to my dogs. I researched the ingredients and am thinking about finding a human version of this stuff. I think the company has done a stellar job of researching what will actually help our dogs--and I know there are human supplements, made of approximately the same stuff, that reviewers rave about. I'm 76, but who knows? If I get the same nutrients, maybe I'll be more energetic as well and help chase that darned ball! First post: I got this, despite the price, just to see. My son has a seven-year-old Aussie who was no longer wanting to chase the ball, who stood back and just didn't seem to care about playing anymore with our two younger dogs. It was so sad to see! He is still so young. I remembered reading about Critical Immune Defense and seeing good reviews. So, despite the cost, I decided to order some. I gave my grand-dog, Gus, his three scoops (he's a larger dog than my girls, so they only get two) on his food per meal for three days. (I did mention to my son that I was doing so. It is his dog, after all.) So we sailed along for three days, and all of a sudden, my grand-dog, Gus, began bursting forward to chase the ball and play. He was like a puppy again, all excited and racing around. It made my heart swell, because I was thinking, "That Stuff is actually Working!" My son said nothing. So, I thought, okay, fine. I can do without spending all that money on snake poison, even though I believed I was seeing a huge change in my grand-dog, Gus. My thought was, "I saw a placebo effect. I convinced myself, so I believed in the hype." My son didn't mention seeing a difference. So, hello, the stuff is expensive. I decided not to buy anymore. I'm not an idiot. So a few days later, my son calls. (We live on the same property, so our dogs all eat together.) "Mom, are you still giving Gus his supplement?" I thought I had messed up, because I wasn't giving him anything. I was, like, WHAT supplement? My son was, like, that stuff that started making him play like a puppy again! He was very upset that I had stopped giving his dog the CID. He would have been eagerly willing to continue the supplement at his own cost and trouble! The difference in the dog was huge. I popped back, saying that he'd never said a word about how it changed Gus. Why would I continue giving it to him? The stuff is costly! (I hope the company can shave away at their overhead to reduce the cost of product. ) Bottom line, this stuff DOES work! It isn't about buying it and only thinking it works. It truly does, and our Gus is suddenly running and playing like a much younger dog. It has given him a new lease on life. I have decided to also give it to my two younger dogs, hopefully as a preventative supplement. And, hello, I'm researching to find a human-grade supplement with mostly the same ingredients. I could stand a boost energy to make me feel better, too!
A**R
My girl !!
2 bottle I’m buying.. my dog had no problem eating this product.. my bull terrier mini female has cancer and over a year ago the vet said to put her down and gave me no options… so I started making my own food and giving herbal supplements including this product.. it appears to be giving my girl high energy being very play ful and happy …. I’m sure if I have not made a quick change she would have been long gone … I recommend this product…..
C**S
Seems like a quality product.
I hope this helps with my dog’s cancer. It gets great reviews from others and he likes the taste. It seems a little expensive but everything is these days. If it helps his immune system it will be well worth it.
S**E
Good but Pricey
This product works well for my lab, but it’s pricey for the amount you receive.
L**E
Received product today! Starting it tomorrow!
This product was received fast and in new condition in a sealed container. I was impressed by that as lately I haven't been getting good products from amazon. This was a pleasant surprise. I will start my dog on this product tomorrow. Praying for a miracle but just a little more time with my dog would be amazing. Here goes. Everyone say a prayer for Sparky! Update: Spark doesn't like taste. I have to hid it in yogurt.
H**1
IF YOU VALUE YOUR DOGS LIFE…DO NOT BUY!!
I never write reviews but Milky my Bichon Poodle almost died. After I sprinkled this product on his food, he refused to eat it. I coaxed him into eating, not realizing the danger. The next morning, he usually jumps down from my bed, but this time he was whining and needed help. When I placed him on the floor, he couldn’t walk—he couldn’t even stand on his own. I lifted him up, and he began limping across the floor. From what I could tell, only one leg was really working. Panicked, I began to pray over him olive oil mix with 2 drops of oil of oregano with black seed and gave him plenty of water to flush the product out of his system. I’m currently unemployed and was praying we wouldn’t have to go to the vet. The whole reason I bought this product was to avoid a vet visit as a preventative measure. He’s 15 yrs, but other than some possible dental issues, he’s generally fine. That entire day, he struggled to walk, limping and needing help up and down the stairs. It was a mess. I even called my pastor, who prayed for him over the phone. Then, late in the night, I heard him jump off the bed. Thank God! The next day, he was doing much better and could walk again—still a little unsteady, but by the evening, it was like nothing had happened. He was back to running around as usual. Stay clear of this stuff! I went back and read the one-star reviews, and I saw that two dogs had died after using this product. If I had seen those reviews earlier, I never would have bought it. Of course there’s no refund. If your dog refuses to eat something, trust them. Do not push it. I’m so blessed he made it through.
T**N
Very good to have for dogs
Best powder supplement for my dogs all 3 dogs get it on top of their food every morning my 2 older senior dogs are more active now than when I got them in nov. 2025 will continue to buy for them it's great to wake up every morning and see them acting young again they are more alert to. By greeting me at the door everyday when I return home from being out
G**.
My dog seemed not to mind the taste/smell
I started using this product after my dog was diagnosed with lymphoma...unfortunately, after two and a half months the cancer had spread throughout her body...I'm not sure if I believe the testimonials with people saying it helped their pet fight cancer, allowing them to live for many years....I'll give 3 stars for the fact seem didn't seemed to mind the taste/smell when mixed with her food.....R.I.P. Cynder 🙏🏼💔
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