Jarrow Formulas SAMe 400 mg Extra Strength - Naturally Derived S-Adenosyl Methionine & Active S,S Form - Dietary Supplement - 60 Tablets - Supports Balanced Mood, Joint Health & Liver Function - Vegan

Ottimo, lo ricomprerei volentieri

Super efficace , mon mari et moi avons retrouvés une vie. Nous avons fait une cure de 3 mois ensemble et aujourd'hui, nous sommes aussi efficaces qu'à notre première rencontre. Nos ados ne nous reconnaissent plus et notre entourage n'arrive pas à nous suivre ni au boulot ni club . ☺

The product is good quality but it's shipped in a bubble-pack envelope which results in the product's box being crushed and several of the blister packs being ruptured. SAMe is ruined by exposure to air and moisture so that's an unacceptable waste with such an expensive supplement. This has happened with both of two odors I have received. this product should be shipped in a carton so that it can't be crushed.

I've always battled mild'ish depression and mild-to-severe anxiety. Many supplements may help ease depression and anxiety, but it often comes at the cost of having side-effects (e.g. unusual bowel movements). Such is also the case with Sam-e as many folks report a counter-intuitive increase in paranoia and/or anxiety. As the popular saying goes, "your mileage may vary" as the effects of Sam-E vary based on each individual's internal chemistry.Three years ago, I started taking the Nature's Made brand (very commonly found at a local pharmacy) for a short period of time. Folks online reported that effective combating of depression required about 800mg to 1600mg per day in order to see an effect. I was on this regimen for about two weeks and became EXTREMELY PARANOID AND ANXIOUS about the most irrational of things.About a month ago, I re-researched into Sam-E again. New information and user testimonials had come out over the last few years about differences in brand effectiveness, daily dosage, etc. As I alluded to before, some folks may need a high dosage like 1600mg to see a difference. However, I noticed that I only need a fraction of that amount in order to feel better.I started off with Nature's Made and took about a much lower dosage at 400mg (200mg in the morning and 200mg in the afternoon). I felt great after the morning dosage, but the increase in anxiety crept up shortly after the afternoon dosage. No paranoia this time around though. This forced me to think about scaling the daily dosage back to 200mg per day (once in the morning only). After doing so, I started feeling great!Additionally, I have been taking my Sam-E with a B-Complex in the morning. Per Dr. Andrew Weil (which you can search online and read for yourself), he recommends the following to be used alongside Sam-E: "Take a daily multivitamin supplement that provides 400 mcg of folic acid, at least 50 mg of vitamin B6 and 50 mcg of B12 (along with the rest of the B-complex)." Many folks also recommend that you stay very hydrated as another means of helping Sam-E do its job.Here are my experiences:-- I definitely feel more alert throughout the day and have had a happier, more optimistic inclination about the day-to-day stuff in life.-- Similarly, I notice that I don't need as much coffee during the day. Before Sam-E, I needed at least a few (large) cups per day. Now, one cup of coffee in the morning is more than enough.-- I definitely feel as if I sleep better and have more drive to get out of bed in the mornings. Like the Chicken or the Egg argument, I'm sure that getting a more restful night's of sleep is also helping me feel better throughout the day.-- I used to constantly fall asleep during Movies and TV shows in the early evenings. Sam-E has given me an extra boost of energy where I don't prematurely fall asleep.-- Although many have said that Sam-E doesn't drastically help with their anxiety, I noticed that by taming depression, my anxiety has also been reduced. For example, I have felt an increase in confidence; the extra spark of energy has allowed me to give off a healthier vibe towards others (e.g. constant smile, better at holding eye contact, less stuttering/flustering).-- I have also felt motivated to complete my (often mundane) day-to-day tasks, such as cleaning the house, doing the dishes, cook dinner, etc. Similarly, at work, I have seen an increase in successfully meeting my daily responsibilities since taking Sam-E.The downside to Sam-E is that it can be very expensive and not covered by any insurance since it's a vitamin supplement. This forced me to research into cheaper options for Sam-E. Luckily, the Jarrow's brand is highly raved by other Amazon users AND the price is substantially less than buying the Nature's Made version at a local store. I have felt the same positive effects from Jarrow's as I did when using Nature's Made. The only thing to beware is that a few people have said that the effects ARE different between the two brands (both positive and negative) - again, your mileage my vary.Also, Sam-E isn't a "magic bullet" solution. Sam-E can only do so much if you're out of shape and/or are sleep deprived. For example, I am a late-night owl and if I only get a few hours of sleep, I wake up feeling groggy (just as any normal person would). You have to be realistic about Sam-E; it can enable you to feel better but the problem won't entirely go away unless you choose to make other lifestyle changes.*BEWARE OF THE PACKAGING/SHIPPING*The last thing I wanted to point out is to beware of the packaging. I ordered my Jarrow's 200mg directly from Amazon and the packaging was EXTREMELY POOR; the vitamins were stuffed into a small bubble mailer that was clearly not protected from getting "squished." When it arrived, the box inside was compressed into half its size (presumably from having other packages sit on top of it) AND it caused half of the blister packs to break open (leaving the vitamins exposed into the air). As other reviewers have mentioned, Sam-E is very sensitive to air/moisture changes, so I was forced to throw away any tablets that were already exposed.FYI, other vendors will put the vitamins into a small cardboard box stuffed with large air bubbles to protect the item from getting "squished." Granted, other vendors are more expensive but I'm also not throwing away wasted tablets. Although I won't dock stars away from the product (since it's not Jarrow's fault), it is absolutely something that buyers need to be aware of.Note: I am not a licensed clinical professional. Any information provided above is meant to be used for informational purposes only and should not replace the advice of an actual physician.

For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit.SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief.I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available.Within a week of taking SAM-e, I could function. Things were looking up. I was me again.That was two summers ago and would not be without it since.Here's the kicker:I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited.MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12."I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose.I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price.--Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.