

✨ Clear skin, no compromises — your secret weapon against breakouts!
Neutrogena On-The-Spot Acne Spot Treatment Cream harnesses 2.5% benzoyl peroxide in a gentle, fast-absorbing vanishing formula clinically proven to reduce pimples starting day one. Ideal for acne-prone and dry skin, this lightweight cream penetrates pores to kill bacteria without over-drying, allowing up to three daily applications. Packaged in a convenient 0.75 oz tube, it delivers targeted, invisible treatment that fits seamlessly into any professional’s skincare regimen.









| ASIN | B00UOLIOC6 |
| Best Sellers Rank | #1,216 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #45 in Facial Serums |
| Customer Reviews | 4.6 4.6 out of 5 stars (3,897) |
| Is Discontinued By Manufacturer | Yes |
| Item model number | 2620649002 |
| Manufacturer | Kenvue |
| Product Dimensions | 1.45 x 3.95 x 3.95 inches; 0.75 ounces |
| UPC | 070501017906 |
K**E
Neutrogena recommend
Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube I’ve been using this On-the-Spot acne treatment from Neutrogena for a while now, and I’m really impressed with the results. The cream is thin and easy to apply, and it absorbs quickly without leaving my skin greasy. I’m already used to using it, and I’ve honestly never been disappointed any day I apply it on any small imperfection I have. It helps dry out pimples fast while still being gentle on my skin. A small amount goes a long way, and I would definitely recommend it to anyone dealing with breakout☺️
K**S
LADIES OVER 40!!!!!! This works for Hormonal acne
5 Stars!!!!! Excellent product for those over 40 whose face decides that hormonal acne is fun. I have been fighting acne on my chin for months..i got desperate and smart....this cleared it up in 3 days. My skin is back to normal and no more painful, icky redness and bumps. Make sure that you use a moisturizer to help with the drying process. I applied at night before bed and then before I put on makeup.
A**Y
10/10!!
Honestly, I didn’t expect this to work. I was using a 10% for my hormonal acne & found it to be too drying. This one works GREAT. It doesn’t overdry your skin but does dry out the pimple depending on how much you use it!
S**I
A Dermatologist-Approved Miracle Worker for Stubborn Breakouts!
★★★★★ A Dermatologist-Approved Miracle Worker for Stubborn Breakouts! After a decade-long battle with acne, I can confidently say Neutrogena's On-The-Spot Acne Treatment is one of the most effective over-the-counter solutions I've ever used. This 2.5% benzoyl peroxide formula delivers professional-level results without the harsh side effects of stronger prescriptions. Why This Spot Treatment Stands Out: ✔ Clinically Proven Efficacy - Visible reduction in redness and swelling within just 8 hours of application ✔ Gentle Yet Powerful Formula - The 2.5% benzoyl peroxide concentration is strong enough to combat acne bacteria while being gentle on sensitive skin ✔ Vanishing Technology - Leaves no white residue or chalky finish (unlike most BP treatments) ✔ Precision Application - The slim tube allows for targeted treatment without wasting product ✔ Dermatologist Recommended - Backed by decades of Neutrogena's skincare science Real Results I've Observed: Overnight Transformation: 90% reduction in pimple size by morning Preventative Power: Regular use prevents new breakouts from forming Skin-Friendly: No excessive dryness or peeling when used as directed Pro Tips for Best Results: Apply a thin layer to clean, dry skin before bed Follow with oil-free moisturizer if prone to dryness Use at first sign of breakout for maximum effectiveness Final Verdict: This tiny but mighty tube has earned a permanent place in my medicine cabinet. It outperforms more expensive alternatives and delivers consistent results without irritation. For anyone struggling with occasional breakouts or persistent acne, this is hands-down the most reliable spot treatment available without a prescription. Worth every penny - my skin's emergency responder!
A**D
Neutrogena has great products .
Neutrogena has great products. I use it for my face and it helps contour my psoriasis.
N**N
Highly recommend effective, gentle, and affordable!
⭐️⭐️⭐️⭐️⭐️ Actually Works Fast and Gentle! I’ve tried so many acne spot treatments, but the Neutrogena On-The-Spot Acne Treatment Gel is one of the few that actually works without completely drying out my skin. The 2.5% benzoyl peroxide strength is strong enough to reduce pimples quickly but still gentle enough for sensitive skin. I use a small amount at night on breakouts, and by the next morning, the redness and size are noticeably smaller. It absorbs fast, doesn’t sting, and layers well under moisturizer or makeup. A little goes a long way, so the tube lasts a while. If you’re looking for a reliable spot treatment that clears pimples without irritation, this is it. Highly recommend effective, gentle, and affordable!
L**Y
Definitely recommend!
I don’t get blemishes very often, but when a painful, red bump appears, I apply On-The-Spot right away and by the next day it’s gone. The tube I had lasted five years and when it ran out I was afraid it was no longer available. I was so happy to find it here. Definitely would recommend; easy to use and quickly resolves the problem.
E**A
A tiny dab will do and you won't regret it!
We all know our skin changes as we do through the years. I didn't develop acne until my 30's and have struggled to find the right treatments. This works effectively and quickly. Don't use too much as it can really dry out your skin. A tiny dab will do!
J**N
It works in just one application! Highly recommended.
T**I
Pimples are visibly better after just one application. Got this for my teenager. He loves it too.
K**G
The product works well for me and is light on the skin. The delivery was fast
M**N
Burn my skin
S**O
Did help to reduce pimples size and only after using for a day or two
Trustpilot
3 weeks ago
1 month ago