When adding new fish or changing water do I have to use the entire 5ml/10gallon rule ?

I would do it if it were me. Most fish come from pet stores that are severly overstocked and under maintained so they are already stressed when you bring them home. Add to that the fact that they are being moved for the umpteeth time and they can use all the help they can get. I will say that I do use half doses when I move my fish from one tank to another only because they tanks are well maintained and the water parameters are pretty much the same so the fish are less stressed. Other people may have different opinions but this is my process and it works for me. I have four tanks. I have a 125, 90, 55 and a 40. I have been in the hobby for over 15 years. I also keep two aquatic turtles as well. Hope this helps.

any views on this product versus API's stresscoat?

Different products, API is a water conditioner, stressguard is an antiseptic for open wounds, cuts. I used StressGuard occasionally and API on water changes.

Do you have to remove purigen from your filter

No. Generally Seachem products are safe to use with other Seachem products. Normal filters, nor purigen filters have to be removed when using Stress Guard. It's perfectly safe.

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Seachem StressGuard Slime Coat Protection - Stress and Toxic Ammonia Reducer 500 ml

Product ID: 3983083

Details

Brand
Seachem
Item Form
Liquid
Item Weight
1.2 Pounds
Liquid Volume
500
Unit Count
16.9 Fluid

🐟reduces fish stress & ammonia toxicity

🧪pH neutral (7.0) formula

🩹promotes wound healing & infection prevention

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VT9388

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Details

Brand
Seachem
Item Form
Liquid
Item Weight
1.2 Pounds

Description

🐠 Heal, Protect, Thrive — Because Your Fish Deserve the Best!

DUAL ACTION DEFENSE - Simultaneously reduces toxic ammonia and stress during fish handling or transport.
STRESS FREE AQUATIC CARE - Neutral pH ensures safe use in reef & planted tanks without disrupting water chemistry.
INSTANT SLIME COAT SHIELD - Premium colloidal agents bind to wounds, creating a protective barrier that accelerates healing.
SAFE FOR ALL AQUATIC LIFE - Formulated to protect fish while being harmless to invertebrates and plants alike.
TRUSTED BY HOBBYISTS WORLDWIDE - Backed by 30+ years of scientific expertise and glowing user testimonials.

Seachem StressGuard is a scientifically formulated aquarium conditioner designed to reduce fish stress and ammonia toxicity while promoting rapid healing of wounds through a unique protein-binding colloidal agent. Its pH-neutral formula ensures safe use in all freshwater and reef aquariums, making it an essential treatment for fish transport, injury recovery, and overall aquatic health.

Specifications

ASIN	B001F0KX06
Allergen Information	Gluten Free
Best Sellers Rank	#4,228 in Pet Supplies ( See Top 100 in Pet Supplies ) #20 in Aquarium Water Treatments
Brand	Seachem
Brand Name	Seachem
Customer Reviews	4.8 out of 5 stars 4,080 Reviews
Global Trade Identification Number	00000116052306
Included Components	Seachem StressGuard 500ml
Item Form	Liquid
Item Type Name	Aquarium conditioner
Item Weight	1.15 Pounds
Liquid Volume	500 Milliliters
Manufacturer	Seachem Laboratories, Inc.
Manufacturer Part Number	523
Model Number	523
Pet Type	Fish
Target Species	Fish
UPC	000116052306
Unit Count	16.9 Fluid Ounces

Reviews

J**E

1.02.2026

R**E

2.09.2024

C**Y

25.11.2025

S**R

7.03.2026

C**E

11.04.2026

S**D

23.06.2023

A**R

19.04.2022

R**A

9.01.2026

R**S

27.03.2026

H**N

4.05.2024

V**F

16.11.2023

S**N

6.12.2019

D**N

9.12.2016

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