NOW Foods Supplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules

The media could not be loaded. [+] WHITE GLOVE REVIEW [w/ VIDEO]I use this product to reduce inflammation in my hands. In the morning, my hands started to become inflamed. They felt bloated/puffy, it was difficult to move my fingers, my joints hurt a little bit, and they were stiff (i.e., not flexible). They didn't look swollen, they just felt that way. This happened when I woke up, but then they would return to normal during the day as I became active. Sometimes I only felt the effects for 5-10 minutes, and sometimes it lasted for hours.I have a background in nutrition, so I realized this could be a symptom of systemic inflammation. I know of two good causes of systemic inflammation, which are an imbalance of Omega-3 to Omega-6's and high homocysteine levels. I tried taking extra fish oil to help balance out my Omega-3 to -6 ratio, but that didn’t help. I was already taking extra B-12 and Folate, but I was not taking extra B-6. All three are needed to regulate homocysteine levels. I started taking Now P-5-P along with B-12 and Folate. The next morning, I felt a noticeable (about 50%) improvement. I kept taking all three once a day in the evening. Each day I noticed more improvement. It took somewhere between 1-2 weeks before my symptoms were about 95% gone. Eventually, all my symptoms disappeared (I didn’t keep track of how long it took). Now, when I wake up in the morning, my hands have no discomfort and work like normal (i.e., no inflammation and perfectly flexible).[+] HOMOCYSTEINE CYCLEThe important thing to note is that all three (B-6, B-12, and Folate) need to be taken. Remember, I was taking two of the three and I still experienced elevated homocysteine levels. I will include links below for the products I take.It is my opinion that the homocysteine cycle is not very well understood by nutritionists or treated properly as a cause of inflammation. You can google it to find out more about it. Also, it is likely that only an older person might experience this, but there is no reason it might not happen to a younger person as well (just not as likely).[+] USAGEI take all three once per day. The B-6 and Folate can be taken on an empty stomach. The B-12 is taken with a lozenge under the tongue. The B-6 (P-5-P) provides about 33mg. Keep in mind that the upper limit for B-6 is 100mg per day. Therefore, I take 1 or 2 per day at the most if I have symptoms, and I only take 1 per day for maintenance. There are days that I skip it all together, and I am fine as long as I do not go too long without taking the vitamins. One time I went too long (over a week) without and the inflammation started to return. I started taking the vitamins again, and the symptoms disappeared right away. The B-12 and Folate have no upper limit, so you can take more, but I have found that one per day is sufficient. Warning: This form of Folate IS NOT Folic Acid. Folic Acid does have an upper limit and ingesting too much Folic Acid in foods or supplements can be problematic as noted by some studies.It is worth noting that I also take a high-quality multi-vitamin, which contains B-6, B-12 and Folic Acid. As we age, there are some situations where a therapeutic dose might be needed, which means that the amounts in the multi-vitamin are not enough. It’s not that the multi-vitamin has an incorrect dose; it’s that my needs require a higher dose for these three vitamins.[+] PRODUCTS (other than this one)NOW Methyl B-12 1,000 mcg,100 Lozenges (My Review: https://amzn.to/2Cmc73R)Now Methyl Folate, 1000 mcg, 90 TabletsThis one was talked about in the video:Source Naturals MegaFolinic 800mcg - 120 TabletsThe multi-vitamin I take is:NOW Foods Adam™ Men's Multiple Vitamin - 180 Softgels (My Review: https://amzn.to/2M7Jb45)GIVE Reviews - my standard for writing reviews[G]enuine - Honest, trustworthy review intended to help people in the Amazon family.[I]nformational - Provide information related to this product in a concise matter.[V]aluable - Provide value to the reader to help determine if this product is for them.[E]nlightening - This review needs to go beyond product information such that the reader learns something they did not otherwise know.[+] Where is the VIDEO & HELPFUL button?If you are viewing in a pop-up window after clicking the photo, then the video and helpful button will not show. To watch the video or up-vote the review, access the review's page using the following link: https://amzn.to/2QAH3lFps. remember to up-vote if you like this review or you think this review will help others.

Quality product from NOW. P5P is essential for folks that have problem with absorption of B6 in other forms. I like that it's in capsule as a single product so it's easy to adjust dose if you feel like it's a bit much on a daily basis.

I read an article recently, that B6 daily dose (50 mg, no more than 100 mg) could help reduce anxiety, so I ordered it. I have sleep issues, so I thought it might help - I started taking one a day about two weeks ago. I do feel stress levels are lower, and my sleep has improved a little bit. The other surprise was healing of a skin rash - some eczema I have had for several years now. The dermatologist prescribed steroid topical cream for it - I have been using that for a very long time, and it's shown very slow gradual improvement. But the same rash has healed faster in the last two weeks, with this vitamin pill once a day, than it did in last two years with the prescription cream. At this rate, I expect it will fully heal within another month. That has been a wonderful surprise - no dermatologist or doctor ever mentioned a vitamin supplement could help with this so fast!

On June 2nd my thumb stated locking and popping. It was quite painful. A few weeks later the thumb remained locked in the open position. I could move the thumb at the base, but could not flex it at the joint near the nail. Using my left (non dominant) hand was generally fine. However, I was unable to use my left hand in tugging motions like pulling up my socks, wrapping the elastic around my pony tail, and when lifting heavy items I had to be extremely careful. The sharp pain could come out of the blue. Just days before the first steroid shot the pain ended and I could confidently use my left hand even though I could not bend my thumb. The injection at the end of July did not help. The second shot at the end of August did not help. A couple days later I started taking one of these supplements every day. The next step was to be surgery at the end of September. I had already decided not to move forward with the surgery since my activities were in no way limited and I was not in pain.Three weeks after the second injection and the start of these supplements my thumb was able to bend. I noticed it in the car on my way home from running errands yesterday. It still locks and pops- but without pain. The locking is less pronounced as the day goes on. When I first woke up flexing the thumb was much more difficult- but not impossible. So there still is a bit of an issue. But it has been 24 hours and I can still bend my thumb. I take this as a positive sign since I have not managed this movement for the past three months.Was it the supplements? I have no idea. Trigger thumb can resolve itself without any intervention. But mine started three and a half months ago. I also had two steroid shots. I was told that if they were going to work that it would happen in about 24 hours. Well it has been three weeks since the last one. So maybe it was the supplements, maybe not. But for the small investment it would be worth giving these pills a try.