Seeking HealthB-Minus, Vitamin B Complex to Support Methylation, MTHFR Support, Methyl-Free, Niacin, Biotin Supplement for Women, Vegetarian Capsules (100 Capsules)*

Capsules are not huge! I take a high dose methylated B12 and folic acid that I have not found in a standard B complex. This lets me do what my neurologist suggested and my B levels are now normal. No burping from B6. Its great. My bloodwork proved it.

We have been looking, for years, for a B-vitamin that we can tolerate. We have MTHFR polymorphisms in my family (where folic acid doesn't convert very well to folate, and it competes with folate in the body), so we can't use a regular multi with folic acid. On top of that, we seem to be sensitive to methylation (methyl B-12 seems to overwhelm us). We've also discovered sensitivity to the normal form of B6. Can you tell we're fun at parties??That being said, Dr. Lynch has really done the MTHFR community (or for anyone who is really sensitive to drugs or vitamins) a huge favor in coming out with this product. It seems safe for those on restricted diets (no gluten, dairy, etc.). The pills are the type where you can actually open them and make the dose smaller if you have empty capsules at home (you can buy them for this purpose).I've been taking these for three weeks and am very happy with how my body tolerates them. I tend toward overmethylation on methyl b-12 and methylfolate. No jittery feeling. Very nice. Another family member (who is likely undermethylated) indicated itching after taking them, possibly from the niacin, as it's not the no-flush form.

I LOVE this product for giving me the basics, but letting me pick my B12 and a couple of others. For those of us with DNA issues to address, this is perfect. And it doesn't trigger my FODMAP reactions either.

This is perfect for what I need except that there is more niacin than needed. Be aware that it can cause a real flush. Harmless, but annoying.

Great to have all B Vitamins in one supplement, works well for me.

Great products by a reputable company. My wife has the MTHFR genetic defect which began cascading into numerous health issues, auto-immune problems. I knew nothing about this several months ago, and honestly not one of her doctors (even fairly open-minded functional medicine doctors) could help her.After she researched Amy Yasko and Dr. Lynch she has been on a path to recovery. Certainly, Dr. Lynch's work (of Seeking Health) has helped tremendously, and these vitamins are designed specifically for people with her health issues.I also began taking Seeking Health vitamins and I noticed a pick-up in energy and I no longer need that afternoon nap which was almost mandatory to make it through the day. I now believe using the correct type of B Vitamins are essentially to thrive.I have to comment on one interesting side note from taking these vitamins as well. I have naturally lost my taste for alcohol. I did not have a problem with it. I certainly enjoyed 2 or 3 glasses of wine or beer with dinner maybe 4 or 5 times per week. But taking B vitamins have eliminated my desire. Strange? It's the only thing that has changed in my diet.

Waaaay too much thiamin had really bad reactions. If you’re sensitive like most histamine people are I’d be very careful with this one.

I did a 23andme genetic test and they asked if they could clone me since they never saw such a perfect male specimen before. I said no, because I plan to live forever. So far, so good ;)And despite not having many flaws, I still find this to be an excellent general use B complex and not just for those with MTHFR issues. Why this one? The Vitamin B6 Paradox on researchgate says that the Pyridoxine form of B6 can inhibit the active P5P form, so the more you take of that form, the more it can work against you and cause deficiency symptoms of B6. It also can lead to neuropathy using that form in excess. And this was one of the B complex that used only P5P even before knowing about that. It also has a good amount of B5 which is great for the adrenals and as a magnesium cofactor to raise magnesium. They also listen to customers such as reducing niacin when customers reported flushing too often. Maybe I just happen to walk by them and it wasnt from the B complex ;) All the B's tend to deplete with stress as well, and B12 and Folate I can add as needed and this ensures I can potentially use a B complex even when not needing more B12.So hopefully your grand kids will enjoy their millions that I spent on your vitamins over the next 100 years. And should remove the biotin and biotin for women as the marketing, its a great b complex for everyone.Has my review been of help to you? If so, would you consider hitting the "helpful" button below? I'd greatly appreciate it. Thank you!